|NEW RESEARCH ON NEUROLOGICAL DISORDERS! |
This week’s discussion is based on a research paper that Chris found and was only published on 18th of June 2022. There was one particular conclusion from the research that captured my attention:
BCP may prevent or delay the onset of neurological disorders!
Now that’s pretty exciting news!
Firstly, before we dive too much into the research, let’s just establish what is a neurological disorder.
There are many nervous system disorders, here are just a few:
Acute Spinal Cord Injury
Amyotrophic Lateral Sclerosis (ALS)
Epilepsy and Seizures
Lumbar Disk Disease (Herniated Disk)
Stroke (Brain Attack)
Types of Muscular Dystrophy and Neuromuscular Diseases
I’m sure you would agree, anything that can prevent or delay ANY of these would definitely be worth looking into.
Ok then, so what did the researchers have to say? (My amendments for easier reading)
Inflammation and oxidative stress are interlinked and interdependent processes involved in many chronic diseases, including neurodegeneration, diabetes, cardiovascular diseases, and cancer. Therefore, targeting inflammatory pathways may represent a potential therapeutic strategy. Emerging evidence indicates that many phytochemicals extracted from edible plants have the potential to ameliorate the disease phenotypes. In this scenario, ß-caryophyllene (BCP), a bicyclic sesquiterpene, ….. demonstrated to exhibit anti-inflammatory, and antioxidant activities, as well as neuroprotective and mitoprotective effects in different in vitro and in vivo models.
BCP essentially promotes its effects by acting as a selective agonist and allosteric modulator of cannabinoid type-2 receptor (CB2R). BCP can readily cross the BBB (Blood Brain Barrier) and accumulate in brain regions, giving rise to neuroprotective effects by preventing mitochondrial dysfunction and inhibiting activated microglia, substantially through the activation of pro-survival signalling pathways, including regulation of apoptosis and autophagy, and molecular mechanisms related to mitochondrial quality control. Findings from different in vitro/in vivo experimental models of Parkinson’s disease and Alzheimer’s disease reported the beneficial effects suggesting that use in treatments may be a promising strategy in the management of neurodegenerative diseases aimed at maintaining mitochondrial homeostasis and ameliorating glia-mediated neuroinflammation.
The conclusion was:
BCP (has) caught a great deal of attention due to (its) ability to reduce OS-induced (Oxidative Stress) free radicals via an antioxidant effect and in managing inflammation through the control of several pathological pathways, as described in different experimental models. Therefore, (BCP) show high BBB permeability and afford a safe approach to protect against the neuronal damage in neurodegenerative diseases via the suppression of microglia-mediated neuroinflammation, as well as in promoting mitochondrial protection. Therefore, although further experimental studies and clinical trials are needed to better evaluate the potential neuroprotective efficacy, BCP may represent (as a) promising candidate to prevent or delay the onset of neurological disorders. In this regard, given the lack of toxicity and easy availability from natural resources it will be crucial to explore the chance of their direct employment as supplements in clinical practice.
The Canna Oils team are regularly asked if we take Canna Oils BCP ourselves. Our answer is always a definitive YES! Personally for myself, beside the benefit of a great night sleep and a calmer countenance, I take Canna Oils BCP as a preventative against dis-ease and this research just makes me even more determined to stick with it!
What about YOU???