NATURAL SLEEP REMEDY – PATHWAY BREAKDOWN (HOW IT WORKS)!!!

We are often asked what makes the Canna Oils – Sleep In A Bottle different to other natural sleep aids.  Well, there are actually a few things that make our sleep blend a stand-out – 4 things actually!!!

Our sleep blend is a carefully crafted, all-natural tincture that targets multiple sleep-regulating systems in the body. We have combined a base of hemp seed oil with a spectrum of terpenes, adaptogens, and an array of time-tested sleep herbs.  It works synergistically to calm the mind, soothe the body, and guide you into deeper, longer-lasting restful sleep. So let’s look into the ingredients, find out how they  engage different biological pathways to support restorative deep sleep:

1. Endocannabinoid System Modulation

Key Ingredients: Beta-caryophyllene (BCP), Nerolidol, Myrcene, Limonene
Canna Oils’ signature terpenes are powerful modulators of the endocannabinoid system (ECS), which helps regulate stress, inflammation, and the sleep–wake cycle.

• Beta-Caryophyllene (BCP): Uniquely binds to CB2 receptors, reducing inflammation and anxiety—common culprits of insomnia and sleep disturbances. By activating CB2, BCP promotes a calm physiological state conducive to better sleep quality.
• Nerolidol: Exhibits sedative properties by enhancing GABA signaling downstream of ECS activity, gently quieting neural circuits to ease the transition into falling asleep fast.
• Myrcene & Limonene: Myrcene increases cell membrane permeability to cannabinoids, amplifying their effects, while limonene elevates serotonin levels, reducing tension and fostering relaxation for sleep.

2. GABAergic Calming

Key Ingredients: Valerian Root, Skullcap, Passionflower, Lemon Balm, Hops, Chamomile
The neurotransmitter GABA is the brain’s primary “off switch” for neural excitation. Sleep In A Bottle includes several botanicals that enhance GABA activity, helping you stay asleep longer:

• Valerian Root & Skullcap: Both contain valerenic acid and flavonoids that bind the GABA_A receptor, mimicking the action of mild prescription sedatives to ease anxiety and promote natural sleep aid effects.
• Passionflower & Lemon Balm: These herbs increase GABA levels by inhibiting its breakdown, quieting an overactive mind and smoothing the path to sound sleep.
• Hops & Chamomile: Contain compounds that potentiate GABAergic transmission, reducing middle-of-the-night awakenings and preventing sleep interruptions.

3. Adaptogenic Stress Regulation

Key Ingredient: Ashwagandha Root Extract
Chronic stress triggers the HPA (hypothalamic-pituitary-adrenal) axis, elevating cortisol and disrupting sleep architecture. As an adaptogen, ashwagandha helps normalize HPA activity:

• Ashwagandha: Lowers evening cortisol levels and balances stress hormones, supporting a natural decline in arousal at bedtime and helping you stay in deep, restorative sleep longer.

4. Nutrient-Rich Base

Key Ingredient: Hemp Seed Oil
While not psychoactive, cold-pressed hemp seed oil is rich in omega-3 and omega-6 fatty acids—precursors to endocannabinoids—and vitamins that support overall neurological health. This base delivers the active compounds effectively and sustains their absorption overnight, enhancing sleep support.

Putting It All Together

By integrating multiple pathways—ECS modulation, GABA enhancement, HPA-axis regulation, and nutrient support—Sleep In A Bottle offers a holistic, multi-targeted approach to sleep optimisation:

1. Quiets the mind (GABAergic herbs + limonene)
2. Calms the body (ECS-acting terpenes)
3. Balances stress hormones (ashwagandha)
4. Nourishes neural health (hemp seed oil)

This synergy means you not only drift off faster but also enjoy fewer nighttime awakenings, waking up feeling truly refreshed. For best results, start at 7 drops under the tongue and build up if needed, hold for 60 seconds then swallow – about half an hour before bed seems to be the sweet spot for many people.  The search for natural sleep remedies, insomnia relief is over- discover restful nights with Sleep In A Bottle.

Here are some Evidence-Based Studies you can check out!

• β-Caryophyllene & Sleep Loss: A recent review details how β-caryophyllene mitigates sleep loss–induced cognitive impairment via anti-inflammatory and neuroprotective pathways, highlighting its promise as a sleep-supportive terpene (link.springer.com).
• Valerian Root Meta-Analysis: A systematic review and meta-analysis of 60 studies confirms valerian’s benefits on subjective sleep quality and anxiety reduction, making it a well-supported GABAergic sleep aid (journals.sagepub.com).
• Ashwagandha RCT: A meta-analysis of five randomized controlled trials found that Ashwagandha extract significantly improved overall sleep quality (SMD –0.59; 95% CI –0.75 to –0.42), supporting its adaptogenic role in stress-related insomnia (journals.plos.org).
• Chamomile Quality Sleep Trial: A randomized, placebo-controlled pilot trial showed chamomile extract improved subjective sleep quality in adults with chronic insomnia, demonstrating its mild but meaningful sedative effect (bmccomplementmedtherapies.biomedcentral.com).

And to make is super easy, so that you never have a sleepless night again, we offer 1, 2 or 3 month autoship options via our website!!!

PS:  Results vary person to person (not suitable for pregnancy or children).

Your Health Matters!

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As always, consult with a healthcare professional before incorporating any new supplements into your routine.