CB2 receptors – a gateway to pain relief

I’d think it would be safe to say that the majority of people that speak to us at events are looking for relief from pain!  And all types of pain – nerve, muscular, inflammation, migraines etc.  Unfortunately, pain is a complex and universal human experience, and finding effective ways to manage it is a constant pursuit for many. But fortunately, in recent years, scientists have turned their attention to the endocannabinoid system (ECS), a network of receptors and signalling molecules within the human body. Among these receptors, is the CB2 receptors, which when activated, have emerged as key players in the modulation of pain perception. Today, we’ll take a closer look behind CB2 receptors and explore how their activation holds promise for reducing pain.

Revision – The Endocannabinoid System (ECS):

The ECS is a complex regulatory system found in humans and other animals (yes, your pets can use Canna Oils BCP too). It consists of three main components: endocannabinoids (endo – just means naturally occurring), receptors, and enzymes.

CB2 Receptors and Pain:

CB2 receptors are primarily found in the peripheral tissues of the immune system.  Unlike CB1 receptors, which are abundant in the central nervous system, CB2 receptors are more focused on regulating immune responses and inflammation. When activated, CB2 receptors play a crucial role in dampening the immune system’s inflammatory signals, leading to a reduction in pain.

Activation Mechanism:

The activation of CB2 receptors can occur through the binding of endocannabinoids or external cannabinoids (such as Canna Oils BCP) found in plants. When the body undergoes stress or injury, it produces endocannabinoids that bind to CB2 receptors, initiating a cascade of events that modulate immune responses and inflammatory processes.  Or if the body isn’t producing enough endocannabinoids, supplementing with Canna Oils BCP can assist.

Reducing Inflammation:

One of the primary ways CB2 receptors contribute to pain relief is by modulating inflammation. In response to tissue damage or infection, the immune system releases pro-inflammatory molecules. CB2 receptor activation helps regulate this immune response, reducing the release of inflammatory signals and, consequently, mitigating pain associated with inflammation.

Altering Pain Perception:

CB2 receptors also influence pain perception by interacting with the vanilloid receptor TRPV1, a key player in the transmission of pain signals. Activation of CB2 receptors can inhibit TRPV1 activity, diminishing the transmission of pain signals to the brain and providing relief from nociceptive pain.Conclusion:

The ECS, particularly the CB2 receptors, offers a glimpse into the body’s intrinsic ability to regulate pain. The evolving landscape of cannabinoid science holds the promise of a brighter future for those seeking effective and alternative pain relief strategies. 

So happy to have found BCP – it’s an absolute game changer!

Sources: Pertwee, R. G. (2008). The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol, and Δ9-tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), 199–215; Hesselink, J. M., Kopsky, D. J., Bhaskar, A. K., & Suarez, A. (2013). Widespread pain relief with an endocannabinoid-oriented diet in multiple sclerosis: Results of a pilot study. Multiple Sclerosis and Related Disorders, 2(3), 212–218; Guindon, J., & Hohmann, A. G. (2008). Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain. British Journal of Pharmacology, 153(2), 319–334; Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, 4(1), 245–259; Pacher, P., Bátkai, S., & Kunos, G. (2006). The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacological Reviews, 58(3), 389–462; McPartland, J. M., & Russo, E. B. (2001). Cannabis and cannabis extracts: Greater than the sum of their parts? Journal of Cannabis Therapeutics, 1(3-4), 103–132.

Disclaimer:  The information in this post is for reference purposes only and not intended to constitute or replace professional medical advice or personal research. Please consult a qualified medical professional before making any changes to your diet, medications or lifestyle. Effects are provided as a guide only.  Statements have not been evaluated by the TGA.