Downregulation? Advantages of BCP over CBD!

Downregulation? Advantages of BCP over CBD! »

Indirect vs. Direct Binding – Does It Matter?

The endocannabinoid system (ECS) is starting to gain significant attention due to its role in regulating various physiological processes in the body. Today, let’s take a closer look at the complexities of one of the receptors found in the ECS, known as the CB2 receptors, and their interaction with the infamous CBD and our amazingly wonderful BCP.

CBD and Indirect CB2 Receptor Interaction

Cannabidiol (CBD), a compound found in cannabis, has been praised for its potential therapeutic benefits. One way CBD affects the ECS is by indirectly interacting with CB2 receptors. Unlike THC and BCP, CBD doesn’t directly bind to these receptors. Instead, it modulates their activity through complex mechanisms, leading to effects like reduced inflammation and pain perception.

However, prolonged CBD use has raised questions about its impact on CB2 receptors.

Down regulation and CB2 Receptors

Prolonged or excessive CBD use has been associated with the down regulation of CB2 receptors. Down regulation occurs when the body, in response to consistent stimulation, decreases the number of receptors present on cell surfaces. This phenomenon can potentially reduce the overall effectiveness of CB2 receptors signalling, leading to diminished therapeutic effects over time.

Enter BCP: Direct CB2 Receptor Binding

Unlike CBD, BCP directly binds to CB2 receptors, initiating a more direct and specific response. This direct binding is thought to result in more consistent and predictable effects compared to the indirect interaction of CBD.

Advantages of Beta Caryophyllene

  1. Specificity and Consistency: Direct binding means that the effects of BCP on CB2 receptors are likely to be more targeted and consistent. This is especially important for individuals seeking reliable therapeutic outcomes.
  2. Potential Amplification of Effects: BCP ‘s direct binding may lead to a more pronounced and immediate response, making it potentially suitable for acute conditions or situations requiring rapid relief.
  3. Mitigation of Down regulation: By directly binding to CB2 receptors, BCP may help mitigate the down regulation phenomenon associated with prolonged CBD use. This could be particularly beneficial for individuals requiring long-term ECS modulation.
  4. Synergistic Effects: Some studies suggest that BCP could enhance the effects of other cannabinoids by acting as a CB2 receptor activator. This potential synergy might amplify the overall therapeutic potential of cannabis-derived compounds.


In the realm of cannabinoid therapeutics, the interaction between compounds like CBD and BCP with CB2 receptors is fascinating. While CBD’s indirect modulation of CB2 receptors is widely known for its benefits, concerns about down regulation warrant consideration. BCP ‘s direct binding, on the other hand, presents a potential solution to the down regulation issue, offering advantages like specificity, immediate effects, and potential synergistic action.

I’m not suggesting in any way that CBD is not effective – but we often speak with CBD users, that tell us that over time they have needed to significantly increase their dose or come off it completely to give the receptors a break. The above research simply suggests that because BCP binds directly, we can activate the same receptor and not have these tolerance issues.  So for me, that’s great news that needs to be shared!


Disclaimer:  The information in this post is for reference purposes only and not intended to constitute or replace professional medical advice or personal research. Please consult a qualified medical professional before making any changes to your diet, medications or lifestyle. Effects are provided as a guide only.  Statements have not been evaluated by the TGA.

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