Schizophrenia symptoms linked with CB2 receptor

This week, I discovered two studies that looked into the link between schizophrenia symptoms such as, hyperactivity and impaired information filtering and the CB2 receptors in our brain.  I found these studies interesting due to the fact that Canna Oils Beta Caryophyllene (BCP) directly binds these CB2 receptors.  So I think it’s worth taking a closer look.

STUDY 1:

This study challenged the pre-conceived idea that CB2 receptors were only found in the peripheral area of the body.  But what they found was groundbreaking – we have CB2 receptors in the brain as well.  They discovered that these receptors are actively involved with many of the brain functions and behaviours.  They found the receptors were involved in both normal and abnormal brain conditions. Moreover, these brain CB2 receptors appear to have a protective mechanism, increasing in number to shield the brain from harm when necessary.

STUDY 2:

The second study, published in late 2023, explored symptoms associated with schizophrenia, such as hyperactivity and impaired information filtering. Remarkably, researchers found a link between diminished sensitivity to CB2 receptors and the exacerbation of these symptoms.

THE ROLE OF BCP:

Given these findings, then I would presume that substances that are known to activate or increase the “sensitivity” of these receptors are of considerable interest. There’s loads of research that confirms that Beta Caryophyllene (BCP) is a CB2 receptor agonist. This means that it has the ability to bind directly to and activate CB2 receptors.

By doing so, BCP could potentially exert therapeutic effects in conditions where CB2 receptor activity is implicated. Activation of CB2 receptors by BCP may modulate neuroinflammation, promote neuroprotection, and regulate neurotransmitter levels, thereby offering a promising avenue for alleviating symptoms associated with hyperactivity, impaired information processing, and other behavioural abnormalities.  I really to hope that scientists continue to research into the specific effects of BCP on CB2 receptor activity and its impact on schizophrenia-related pathways so we can fully understand its therapeutic potential in treating these conditions.

Sources:https://pubmed.ncbi.nlm.nih.gov/38135096/‘ https://pubmed.ncbi.nlm.nih.gov/30611802/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163236/

Disclaimer:  The information in this post is for reference purposes only and not intended to constitute or replace professional medical advice or personal research. Please consult a qualified medical professional before making any changes to your diet, medications or lifestyle. Effects are provided as a guide only.  Statements have not been evaluated by the TGA.